Studies on antiviral agents. V. Synthesis and in vitro antiviral activity of new aminoglycoside derivatives having palmitoyl group.
نویسندگان
چکیده
The synthesis and antiviral activity of various aminoglycoside derivatives having a palmitoyl group are described. All of these aminoglycoside derivatives exhibited almost the same excellent antiviral activity against herpes simplex virus type I and influenza virus.
منابع مشابه
Studies on antiviral agents. III. Synthesis and in vitro antiviral activity of 1-N-higher-acyl-3"-N-functionalized acylkanamycin A derivatives.
The synthesis and antiviral activity of 1-N-palmitoyl- or 1-N-(3-hydroxytetradecanoyl)-kanamycin A derivatives (7,8) having various type of acyl substituents at the N-3" position were investigated. The structure-activity relationships between the antiviral activity and the substituent at the N-3" position is described. In this series, 3"-N-acetyl-1-N-palmitoyl-kanamycin A (7c) showed the excell...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 40 6 شماره
صفحات -
تاریخ انتشار 1987